Kluane National Park and Reserve provides prime habitat for many species of wildlife, particularly Dall sheep, Kluane's most abundant large mammal. Visitors often see them foraging on the wind swept slopes of Thechàl Dhâl' in the spring, fall and winter. Mountain goats scramble along rocky cliffs and ledges in the south, and a small herd of caribou occasionally wander through the Duke River area. North America's largest subspecies of moose also range through Kluane National Park and Reserve.
Populations of grizzly bears move between alpine meadow and valleys with the passing of the seasons. Black bears, which prefer forested areas, are also common in Kluane. As well as a transient population of wolves there is also a variety of smaller mammals including: wolverine, muskrat, mink, marmot, red fox, lynx, otter, coyote, beaver, snowshoe hare and arctic ground squirrel.