The federal, territorial and Indigenous Thaidene Nene protected areas permanently protect 26,376 km2 of nationally significant boreal forest, tundra, and freshwater ecosystems in and around the East Arm of Great Slave Lake and beyond. These pristine ecosystems, highlighted by sharp cliffs, deep lakes, and rushing rivers, caribou, muskoxen, wolves, and fish. These healthy ecosystems sustain the culture and livelihood of the Łutsël K'é Dene First Nation, other First Nations, and Métis. 

In partnership with Indigenous governments and organizations, Parks Canada has designated the 14,305 km2 core of Thaidene Nene as a National Park Reserve under the Canada National Parks Act, and the Government of the Northwest Territories has designated the abutting 9,105 km2 as a Territorial Protected Area under the territorial Protected Areas Act and is working on designating a 3,120 km2 as a Wildlife Conservation Area under the Wildlife Act.  The entirety of Thaidene Nëné is designated by Łutsël K'é Dene First Nation as an Indigenous Protected Area.